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Zebrafish are increasingly seen as a promising model organism in which to investigate neurodevelopment because their young, or larvae, are transparent, making it possible to image the whole brain in real time. In this review, we discuss the use of zebrafish as a model organism to study the development of the ENS. The timing of the adoption of zebrafish as an emerging model organism could not be better, as mouse studies often fail to translate to humans. They share many genes with humans, have short generation periods and are easy to maintain. As Zebrafish eggs are fertilized and develop outside the mother’s body it is an ideal model organism for studying early development. Combining this with precise genome editing, it is not so hard to imagine that zebrafish could play a large role in personalized and precision medicine. Injury was reduced by acetylcysteine treatment of paracetamol‐exposed zebrafish, as is the case in humans 4 . Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from South Asia.The ease of care, year‐round prolific breeding, and transparent, external development have made these fish a popular model vertebrate for many fields of biology. 70% of protein-coding human genes are related to genes found in the Zebrafish. Zebrafish As a Model Organism for Developmental Disorders. Classically, the zebrafish model organism has been used to elucidate the genetic and cellular mechanisms related to development since the embryo forms and grows externally following fertilization. 14 15. Also, unlike other animal models, the genes of zebrafish … In vivo model organisms are popular tools for biomedicine researchers globally. This provides insight into the genetic control of developmental processes in humans because their genomes are similar. The general suitability of zebrafish as a model organism, as well as its use in the genetic and neuroanatomical analysis of larval behaviour has been comprehensively described elsewhere [1, 2]. GENETICS 1. The Zebrafish Information Network (ZFIN) is the database of genetic and genomic data for the zebrafish (Danio rerio) as a model organism.ZFIN provides a wide array of expertly curated, organized and cross-referenced zebrafish research data. In a paracetamol‐induced liver toxicity model in adult zebrafish, North and colleagues demonstrated that ALT activity increased in zebrafish in a dose‐ and time‐dependent fashion 66. Although no animal can perfectly model a human disease, I believe these little striped swimmers have great potential for advancing medical research in the future. The accessibility of the rapidly developing gut in zebrafish embryos and larvae, enables in vivo visualization of ENS development, peristalsis and gut transit. The fish also develop rapidly, and researchers can simply add drugs to the water to test the effects. The Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN) is composed of two Centers that use fruit fly (Drosophila melanogaster), nematode worm (Caenorhabditis elegans) and zebrafish (Danio rerio) genetics and biology to tackle rare and undiagnosed diseases.By combining state-of-the-art genetic and … Furthermore, zebrafish is the only vertebrate model organism that has the potential for high-throughput screening for toxic and therapeutic compounds. For many of us, mice and monkeys come to mind when thinking about animal models. Zebrafish are vertebrates often used for in vivo studies, because they are relatively small in size and the embryonic and larval development is ex utero and fast, since within 5 days post-fertilization (dpf), all major organ systems are formed (Kimmel et al., 1995).Zebrafish embryos are virtually … Model Organisms Overview. 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